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Mass Spectrometry of Large Molecules and Non-Covalent Complexes

Summer School at the University of Jyväskylä, Finnland
August 17-21, 2009

Please find here the course schedule and accompanying material related to the topics of the course. The downloads are password-protected. The password will be given at the beginning of the course. The solution transparencies for the case studies will be made available after we discussed them. If you send me the pdf files of your presentations, I will make them available to the participants below (password-protected of course).

Lectures

1. Introduction: The Mass Spectrometer as a Laboratory
2. Methodology I: Soft Ionization Methods
3. Methodology II: Mass Analyzers and Detectors
4. Tandem Mass Spectrometry: How to Investigate the Chemistry in the Gas Phase
5. Solvent Effects I: How Non-Covalent Bonds Change upon Transfer to the Gas Phase
6. Solvent Effects II: Gas-Phase Acidities and Gas-Phase Nucleophilicities
7. Thermochemistry I: Thermochemistry of Isolated Ions
8. Thermochemistry II: The Best-Fit Model for Crown Ether Binding of Alkali Metal Ions

Participants' Seminar Talks

1. Structure by MS I: Peptide Sequencing
2. Structure by MS II: Hydrogen-Bonded Capsules and How to Distinguish Topologies?
3. Structure by MS III: Chiral Recognition
4. Solution-Phase Reactivity: Ligand Exchange Reactions on Helicates
5. Gas-Phase Reactivity I: Dendrimers - Ionization Artifacts and Defects
6. Gas-Phase Reactivity II: Metallo-Supramolecular Squares
7. Gas-Phase Reactivity III: H/D-Exchange Reactions in the Gas Phase
8. Gas-Phase Thermochemistry: Blackbody Infrared Radiative Dissociation

Case Studies

1. Case Study 1: An Example for Peptide Sequencing
2. Case Study 2: IRMPD & ECD for Peptide Sequencing
3. Case Study 3: Pyrogallarene Hexamers
4. Case Study 4: Oligothiophene Catenates and Catenanes
5. Case Study 5: Serine Octamer - A Magic-Number Cluster
6. Case Study 6: Self-Assembly and Self-Sorting at Work
7. Case Study 7: Backfolding in Dendrimer-Tweezer Complexes
8. Case Study 8: A Cage Contraction in the Gas Phase
9. Case Study 9: Crown Ethers on the Spacewalk
10. Case Study 10: Is Watson-Crick Basepairing Conserved in the Gas Phase?

Animations

1. Nanospray Movie 1 (mp4 format)
2. Nanospray Movie 2 (mp4 format)
3. Quadrupole Movie (Adobe flv format)
4. Ion Trap Movie (exe file)
5. FTICR Movie (ca. 50 MB!) (mpg format)